Serum ferritin levels adversely affect cardiac function in patients with ST-elevation myocardial infarction who underwent successful percutaneous coronary intervention

摘要

Several cohort studies have revealed that increased body iron stores raise the risk of ischemic heart disease [1,2]. The characteristics of iron status in patients with ST-segment elevation myocardial infarction (STEMI) are also well known. A decline in serum iron, followed by a decrease in the iron saturation rate of transferrin as a result, and a rise in ferritin levels immediately appear after STEMI [3,4]. However, these biomarkers do not correlate with the amount of ischemic tissue damage as estimated by creatine-kinase levels. Moreover, there have been no reports on the clinical significance or direct evidence of the role of iron metabolism in patients with STEMI.