Incidence and regression of Charles Bonnet syndrome in vascular age-related macular degeneration.

摘要

It appears that the incidence as well as the regression of Charles Bonnet syndrome (CBS) depends on the presence of several retinal circumstances. There is general agreement that symptoms of CBS are frequently reported in eyes with presumably long duration of age-related macular degeneration (AMD), consecutively large subretinal (SR) lesions and poor visual acuity (VA). It is our personal experience that CBS rarely occurs in acute retinal pathologies such as acute retinal pigment epithelial (RPE) tears, SR haemorrhages or recent onset of a geographic atrophy (GA) with a small lesion area. However, clinical signs of CBS may become apparent after 9-12 months, when the final VA remains poor and an enlarged atrophy is observed due to a denuded RPE bed in RPE tears, RPE atrophy after rtPa injections in SR haemorrhages or a large GA. Treating acute choroidal neovascularisation (CNV) with anti-VEGF can reduce inner and SR fluid, increasing the final VA.