Syndrome of inappropriate secretion of anti-diuretic hormone in an elderly depressive patient receiving paroxetine: a case report.

摘要

Paroxetine is a selective serotonin reuptake inhibiter (SSRI) widely used to treat depression. SSRI can also be prescribed to elderly patients with comparative safely because there are fewer serious side-effects of SSRIs compared with those of tricyclic anti-depressants. However, fatal side-effects induced by SSRIs have sometimes been observed. Jacob and Spinier (2006) reported hyponatremia associated with SSRI with an incidence varying from 0.5-32% (Jacob and Spinier, 2006). This case report describes a case of syndrome inappropriate secretion of anti-diuretic hormone (SIADH) in association with paroxetine therapy in an elderly patient. In SIADH, ADH stimulates the retention of water in the absence of appropriate physiological stimuli.