Basic parameters of thrombophilia in ocular Behget disease with posterior segment involvement

摘要

Aim: To assess basic thrombophilic parameters in both active and inactive periods of the ocular Behget disease (BD) with posterior segment involvement in comparison with those in healthy adults as controls. Method: Thirty, patients within the active period of the ocular BD with posterior segment involvement, 30 patients within the inactive period of the ocular BD with posterior segment involvement and 30 age-and sex-matched healthy controls were included in the study. Plasma protein C, free protein S, antithrombin 111 and activated protein C resistance were measured in the studied groups.Results: Activated protein C resistance and antithrombin III levels were significantly altered in both active and inactive ocular BD patients when compared with those in the controls (p<0.05), whereas protein C and free protein S levels were not significantly changed within both groups (p>0.05). There was no difference among the active and inactive groups of BD for all of the studied blood tests (p>0.05).Conclusion: Activated protein C resistance together with increased antithrombin III plasma levels are associated with the posterior segment involvement in ocular BD based on the assessment of basic thrombophilic tests.