眼肌型重症肌无力患者发生眼外肌以外肌群受累的相关因素研究

摘要

Objective To study the related-factors analysis of the affected extraocular-excluded muscles in ocular myas-thenia gravis (OMG).Methods Clinical data of 440 cases with ocular myasthenia gravis in our hospital were retrospectively an-alyzed,who were divided into transformation group and non-transformation group according to the clinical types.And the basic data of the two groups were assessed by univariate analysis to identify the related factors,immediately after that,which were performed by multi-factor linear regression analysis to determine the independent factors.Results The related factors of the af-fected extraocular-excluded muscles in OMG patients,were confirmed by age distribution,RNS anomaly (including the abnor-malities of facial nerve,ulnar nerve and accessory nerve),thymoma,thyroid abnormality and hormone theraPY.Multi-factor a-nalysis showed that the facial nerve,ulnar nerve,thymoma and hormone treatment were considered as the independent factors. Conclusion From the above-mentioned results,We define the facial nerve,ulnar nerve,thymoma and hormone theraPY as the in-dependent factors of the affected extraocular-excluded muscles in ocular myasthenia gravis,which should be gave the highest priories in clinical practice as it can effectively improve the quality of life and prognosis.%目的：探讨眼肌型重症肌无力患者发生眼外肌以外肌群受累的相关因素研究。方法回顾性分析在本院就诊的眼肌型重症肌无力患者440例,根据临床分型将随访患者分为转化组和未转化组,并对2组患者的基本资料做单因素分析,经单因素分析确定相关影响因素,对相关影响因素做多因素线性回归分析,确定独立影响因素。结果眼肌型重症肌无力患者发生肌外群受累的相关影响因素为年龄的分布,RNS 异常(面部神经异常,尺神经异常,副神经异常),胸腺瘤异常,甲状腺异常以及激素治疗,多因素分析结果显示,面神经,尺神经,胸腺瘤及激素治疗为眼肌型重症肌无力患者发生肌外群受累的独立影响因素。结论面神经、尺神经,胸腺瘤以及激素治疗为眼肌型重症肌无力患者发生肌外群受累的独立影响因素,在临床治疗的过程中要对以上检测指标异常的患者提起高度的重视,可有效提高该类患者的生存质量。