Simultaneous amniotic membrane transplantation in emergency penetrating keratoplasty: a therapeutic option for severe corneal ulcerations and melting disorders.

摘要

In cases of severe corneal melting, immediate penetrating keratoplasty (PK) can be required but is accompanied by a high prevalence of complications due to ongoing inflammatory stimuli and wound-healing disorders. In these situations, the properties of amniotic membrane (AM) including promotion of epithelial healing as well as antiangiogenic, anti-infectious, antiscarring and immunemodulatory effects can be beneficial. In the context of PK and AM transplantation (AMT) different surgical approaches are possible: (1) AMT prior to PK; (2) PK with simultaneously performed AM patch, as described in this study; and (3) AMT after PK.