A case of fatal overwhelming microgranular variant (M3v) of acute promyelocytic leukemia with extensive extramedullary involvement.

摘要

A 38-year-old man presented on January 2007 with dyspnea on exertion, cough, hepatosplenomegaly, and fever. WHO performance status was 2. White blood cells at admission were 38 x 109/L (neutrophils 35.6 x 109/L). Lactate dehydrogenase was 1513 U/L (ULN 500 U/L); aspartate transaminase and alanine aminotransferase 308 and 360 U/L, respectively (ULN 45 and 55 U/L). Grade 2 (no bleeding, according to CTCAEv3) disseminated intra-vascular coagulation (DIC) was recorded.