Consumption of polyphenol-rich juar tea increases endothelium-bound extracellular superoxide dismutase levels in men with metabolic syndrome: link with LDL oxidizability.

摘要

Endothelium-bound extracellular superoxide dismutase (eEC-SOD), a major antioxidative enzyme in the vasculature, is involved in anti-atherogenesis by inhibiting low-density lipoprotein (LDL) oxidation. This study sought to investigate whether polyphenol-rich juar tea has beneficial effects on LDL oxidation and eEC-SOD levels in patients with metabolic syndrome (MetS). 20 men with MetS participated in a randomised cross-over trial which compared consumption of 5 cups/day of juar tea with that of a polyphenol-poor tea (barley tea) for 4 wk. Although there was no change in LDL oxidizability after consumption of either tea, juar tea significantly increased eEC-SOD levels by 16% (p < 0.05), whereas barley tea significantly decreased levels by 15% (p < 0.05). It was noteworthy that the changes in eEC-SOD were positively associated with those in LDL oxidizability after tea consumption (r2 = 0.11, p < 0.05). It is concluded that tea polyphenols may provide anti-atherosclerotic effects by inhibiting LDL oxidation through EC-SOD bound to the endothelium.