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Application of D-optimal experimental design method to optimize the formulation of O/W cosmetic emulsions

机译:D最优实验设计方法在优化O / W化妆品乳液配方中的应用

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OBJECTIVE: This study investigates the application of D-optimal mixture experimental design in optimization of 0/W cosmetic emulsions. Cetearyl glucoside was used as a natural, biodegradable non-ionic emulsifier in the relatively low concentration (1%), and the mixture of co-emulsifiers (stearic acid, cetyl alcohol, stearyl alcohol and glyceryl stearate) was used to stabilize the formulations. METHODS: To determine the optimal composition of co-emulsifiers mixture, D-optimal mixture experimental design was used. Prepared emulsions were characterized with rheological measurements, centrifugation test, specific conductivity and pH value measurements. RESULTS: All prepared samples appeared as white and homogenous creams, except for one homogenous and viscous lotion co-stabilized by stearic acid alone. Centrifugation testing revealed some phase separation only in the case of sample co-stabilized using glyc-eryl stearate alone. The obtained pH values indicated that all samples expressed mild acid value acceptable for cosmetic preparations. Specific conductivity values are attributed to the multiple phases O/ W emulsions with high percentages of fixed water. Results of the rheological measurements have shown that the investigated samples exhibited non-Newtonian thixotropic behaviour. To determine the influence of each of the co-emulsifiers on emulsions properties, the obtained results were evaluated by the means of statistical analysis (ANOVA test). On the basis of comparison of statistical parameters for each of the studied responses, mixture reduced quadratic model was selected over the linear model implying that interactions between co-emulsifiers play the significant role in overall influence of co-emulsifiers on emulsions properties. CONCLUSION: Glyceryl stearate was found to be the dominant co-emulsfier affecting emulsions properties. Interactions between the glyceryl stearate and other co-emulsifiers were also found to significantly influence emulsions properties. These findings are especially important as they can be used for development of the product that meets users' requirements, as represented in the study.
机译:目的:研究D-最优混合物实验设计在0 / W化妆品乳液优化中的应用。鲸蜡硬脂基葡糖苷以相对较低的浓度(1%)用作天然的,可生物降解的非离子乳化剂,助乳化剂(硬脂酸,鲸蜡醇,硬脂醇和硬脂酸甘油酯)的混合物用于稳定制剂。方法:为确定共乳化剂混合物的最佳组成,采用D-最佳混合物实验设计。通过流变学测量,离心测试,比电导率和pH值测量来表征所制备的乳液。结果:所有制备的样品均呈白色和均质乳膏状,只有一种均由硬脂酸共同稳定的均质粘性乳液。离心测试仅在仅使用硬脂酸甘油酯共稳定的样品中显示出一些相分离。所获得的pH值表明所有样品均表现出化妆品制剂可接受的弱酸值。比电导率值归因于具有高百分比固定水的多相O / W乳液。流变测量的结果表明,所研究的样品表现出非牛顿的触变性。为了确定每种助乳化剂对乳化剂性能的影响,通过统计分析(ANOVA测试)评估获得的结果。在比较每个研究响应的统计参数的基础上,选择混合减少的二次模型而不是线性模型,这表明共乳化剂之间的相互作用在共乳化剂对乳液性能的总体影响中起着重要作用。结论:硬脂酸甘油酯是影响乳液性能的主要助乳化剂。还发现硬脂酸甘油酯与其他助乳化剂之间的相互作用会显着影响乳液的性能。这些发现特别重要,因为它们可以用于开发满足用户要求的产品,如本研究所示。

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