EFFECT OF NEW HETEROCYCLIC COMPOUND ON CARBOHYDRATE METABOLISM IN DIFFERENT TISSUES OF MALE ALBINO RATS

摘要

The present study is designed to study the effect of a new heterocyclic compound on glycogen, pyruvate and lactic acid contents in tissues to understand the carbohydrate metabolism and its role in male rats. The treatment with ethyl -1 -(5 -chloro -2-oxoindoltn -3 ylldeneamino) -1,2,3,6 -tetrahydro - 4 -methyl -2 -oxo -6 -phenyl pyrimidine -5 -carboxylate compound at dose level of 3 mg/kg/b.wt. for 21 days did cause a mild change in carbohydrate metabolism in reproductive and somatic tissues of treated rats. In order to assess physiological changes in testis, brain, heart, kidney and liver of rats, estimation of glycogen, pyruvate and lactic acid has been under taken. The result showed a mild decrease in glycogen and lactate levels but in contrast,same treatment caused a mild increase in pyruvate levels.