Radiation induced stress proteins.

摘要

The major heat-inducible member of the stress proteins with a molecular weight of about 70 kDa (Heat shock protein 70, Hsp70) is a ubiquitous protein contributing to a number of cellular processes including the protection of cells from apoptosis induced by environmental stress. Recently, we and others could show that a variety of tumor cells, in contrast to normal tissues, have the unique feature of expressing Hsp70 on their plasma membrane [1], Monitoring the clinical outcome (up to 5 years) demonstrated a negative correlation between the Hsp70 membrane status and the overall survival in patients with lower rectal and squamous cell carcinomas of the lung [2],