NF-κB addiction and resistance to 5-fluorouracil in a multi-stage colon carcinoma model

摘要

Colorectal cancer is one of the most frequently diagnosed malignancies in women and men. All systemic treatment options for colorectal cancer are based on 5-ffuorouracil (5-FU), often administered in combination with oxaliplatin or irinotecan. Resistance to chemotherapy is a major obstacle to successful therapy.Nuclear factor kappa light chain enhancer of activated B cells (NF-kB) is a collection of heterodimeric transcription factors. Activation of NF-kB enables cells to protect themselves from environmental stress and its misregulation is associated with chronic inflammation and cancer-related phenomena such as proliferation, cell survival and cell invasion [1]. In colorectal cancer, NF-kB inhibition may overcome resistance against chemotherapy as well as enhance the cyto-toxicity of drugs [2, 3, 4].