Phase II study of first-line chemotherapy with uracil-tegafur plus oral leucovorin in elderly (>= 75 years) Japanese patients with metastatic colorectal cancer: SGOSG-CR0501 study

摘要

Background Oral uracil-tegafur and leucovorin (UFT/LV) therapy for elderly patients with metastatic colorectal cancer (mCRC) requires careful handling in Western countries because of a high incidence (>= 20 %) of grade 3 diarrhea. However, its efficacy and safety for elderly Asian patients have not been investigated.