Spindle cells from acquired immune deficiency syndrome-associated Kaposi's sarcoma lesions express telomerase activity directly relating to the RNA levels of fibroblast growth factor-2.

摘要

Falchetti et at had previously reported in this journal1 that when human endothelial cells (EC) are transplanted in mice together with human brain tumour cells, they survive and contribute to new blood vessel formation (angiogenesis). Noteworthy, these effects are increased when EC are engineered to over-express telo-merase,1 a ribonucleoprotein complex that ensures chromosome stability by maintaining the length of chromosome ends (the telo-meres) constant.2 In view of the fact that angiogenesis is required to nourish a growing tumour,3 the article by Falchetti et al1 highlighted a mechanism for cancer progression.