Effectiveness of Two Topical Treatments With a CombinationFipronil/Amitraz/(S)-methoprene Against Natural Infestations of Mites (Sarcoptes scabiei var. cards) on Dogs.

摘要

The acaricidal efficacy of the novel topical combination of fipronil/amitraz/(S)-metho-prene (CERTIFECT) was evaluated against Sarcoptes scabiei var canis when administrated as topical solution to dogs naturally infested with the mites. A total of 24mixed-breed dogs of both sexes (10 males and 14 females), aged from 0.3 to 5 years and weighing 3.2 to 20.2 kg, were studied in this single-center, randomized, blinded, and controlled trial. Dogs, naturally infested withSarcoptes scabiei var canis as confirmed by skin scrapings collected prior to allocation, were randomly divided into two equal groups. Dogs in Group 1 were not treated. Dogs in Group 2 were treated on Days 0 and 28. At Days 0 (pretreatment), 7, 14, 21, 28 (before second treatment), 41, and 56, four skin scrapings of similar size were taken from different sites with lesions consistent with sarcoptic mange. Lesion scores were assigned weekly at Day 0 (pretreatment), 7, 14, 21, 28 (before second treatment), 35, 42, and 56, and silhouettes identifying the location of the present lesions were completed. The results showed that dogs treated with CERTIFECT* had significantly (p<0.05) lower mite counts than untreated control animals at Days 14, 21, 41, and 56at a percent reduction of 100%, 99.3%, 100%, and 100% respectively. In addition, dogs treated with CERTIFECT had significantly (p<0.05) lower lesion scores than untreated control animals on Days 28, 35, 42, 49, and 56.