In vivo studies of ciprofloxacin (V-CIPROL) on the pathology of colibacillosis in chickens

摘要

Colibacillosis (E coli injections) is responsible for major economic losses to the poultry industry as a result of high mortality during rearing, reduced weight gain and condemnation of birds at the time of slaughter. In recent years, far more attention is being given to this infection since it is discovered to be a troublesome pathogen of poultry because of emergence of drug resistance in E coli together with frequent breakdown of immune status in poultry and non-availability of suitable vaccine against colibacillosis. Keeping above facts in view, the present study was undertaken to observe the effect of ciprofloxacin (V-CIPROL) on the pathology of colibacillosis in chickens. One hundred and sixty seven days old unvaccinated and apparently healthy chicks were procured from Poultry Research Centre (PRC), Nagla, G.B. Pant Univ. of Agri, & Tech., Pantnagar. The chicks were divided into g groups of 20 chicks each (Table-1). From each group, 5 chicks were sacrificed at day 5 and the remaining at day10 and 15 of the experiment. Blood was collected from all sacrificed chicks and isolation of microorganism was attempted on MLA/EMB media. Tissues like liver, heart, intestine, kidney, bursa, spleen and lungs were collected in 10 percent formal saline for histopathological examination. Post mortem examination was also performed on the chicks died during experimentation. Identification of E. coli was done as per method described by Cruckshank, et al., 1975.