Nanofiber Packed Solid-Phase Extraction for the Analysis of Plasma, Urine, and Saliva with High-Performance Liquid Chromatography

摘要

A convenient and green pre-processing method is presented for determining physiological targets and drugs in biological samples using nanofiber-packed solid-phase extraction instead of a traditional cartridge. Biological samples, including plasma (model target molecule is desloratadine), urine (catecholamines), and saliva (cortisol) were used to characterize sample pre-treatment. Nanofiber-based solid-phase extraction sufficiently isolated the compounds from the complex matrixes. The absolute extraction rates were between 52.3% and 85.7%. Because the nanofiber-packed solid-phase extraction cartridge is a small, lightweight, portable, convenient, and labor-saving device, this pre-processing method has great potential for further application.