Prognostic impact of gained chromosomes in high-hyperdiploid childhood acute lymphoblastic leukaemia: A collaborative retrospective study of the Tokyo Children's Cancer Study Group and Japan Association of Childhood Leukaemia Study

摘要

Although the prognosis of high-hyperdiploid (HHD) acute lymphoblastic leukaemia (ALL) is excellent, relapse occurs in 10-15% of cases (Look et al, 1985). A gained chromosome1 is commonly found (Heerema et al, 2000; Kawamata et al, 2008), and previous studies reported a correlation between other chromosome combinations and outcomes. The Pediat-ric Oncology Group (POG) and Children's Oncology Group (COG) demonstrated that the combined gain of chromosomes 4, 10 and 17 (termed as triple trisomy) was associated with a better prognosis (Sutcliffe et al, 2005), and POG data suggested that +4 and +10 (termed as double trisomy) patients had a very low risk of relapse (Harris et al, 1992).