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Physiologically inspired cardiac scaffolds for tailored in vivo function and heart regeneration

机译:受生理启发的心脏支架可实现定制的体内功能和心脏再生

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Tissue engineering is well suited for the treatment of cardiac disease due to the limited regenerative capacity of native cardiac tissue and the loss of function associated with endemic cardiac pathologies, such as myocardial infarction and congenital heart defects. However, the physiological complexity of the myocardium imposes extensive requirements on tissue therapies intended for these applications. In recent years, the field of cardiac tissue engineering has been characterized by great innovation and diversity in the fabrication of engineered tissue scaffolds for cardiac repair and regeneration to address these problems. From early approaches that attempted only to deliver cardiac cells in a hydrogel vessel, significant progress has been made in understanding the role of each major component of cardiac living tissue constructs (namely cells, scaffolds, and signaling mechanisms) as they relate to mechanical, biological, and electrical in vivo performance. This improved insight, accompanied by modern material science techniques, allows for the informed development of complex scaffold materials that are optimally designed for cardiac applications. This review provides a background on cardiac physiology as it relates to critical cardiac scaffold characteristics, the degree to which common cardiac scaffold materials fulfill these criteria, and finally an overview of recent in vivo studies that have employed this type of approach.
机译:由于天然心脏组织的再生能力有限以及与地方性心脏病(例如心肌梗塞和先天性心脏缺陷)相关的功能丧失,组织工程非常适合于心脏病的治疗。然而,心肌的生理复杂性对旨在用于这些应用的组织疗法提出了广泛的要求。近年来,心脏组织工程领域的特征在于在制造用于心脏修复和再生的工程组织支架方面的巨大创新和多样性,以解决这些问题。从仅尝试在水凝胶血管中递送心脏细胞的早期方法中,在理解心脏活组织构建体的各个主要成分(即细胞,支架和信号传导机制)的作用方面取得了重大进展,因为它们与机械,生物学相关,以及体内电性能。这种改进的洞察力与现代材料科学技术相结合,可以对复杂的支架材料进行明智的开发,而这些支架材料是为心脏应用而最佳设计的。这篇综述提供了心脏生理学的背景知识,因为它涉及关键的心脏支架特征,常见的心脏支架材料满足这些标准的程度,最后概述了采用这种方法的近期体内研究。

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