Oral Clindamycin Compared With Sequential Intravenous and Oral Flucloxacillin in the Treatment of Gellulitis in Adults A Randomized, Double-Blind Trial

摘要

Background: Because Streptococcus pyogenes and Staphylococcus aureus are common causes of cellulitis and erysipelas, treatment with an antistaphylococcal (i-lactam is widely recommended. However, during oral treatment, serum levels of these agents are less than the minimum inhibitory concentration of many methicillin-sensitive strains of & aureus for a significant portion of the dosing interval, and consequently, treatment is often initially given intravenously and then orally. Clindamycin is active against most strains of S. pyogenes and S. aureus and, when given orally, achieves adequate serum levels throughout the dosing interval. Treatment of cellulitis with oral clindamycin might provide better outcomes than those achieved with an antistaphylococcal [J-lactam given intravenously and then orally.