SYNTHESIS OF BENZOTHIAZOLE SUBSTITUTED 4-ARYLIDENE-5-METHYL-2,4-DIHYDRO-3H-PYRAZOL-3-ONES AND 3-METHYL-4,5-DIARYL-4,5-DIHYDROPYRAZOLO [3,4-c] PYRAZOLES AS ANTIMICROBIAL AGENTS

摘要

2-(1,3-Benzothiazol-2-yl)-4-arylidene-5-methyl-2,4-clihydro-3H-pyrazol-3-ones(3a-f) were synthesized by stirring a mixture of 2-(1,3-benzothiazol-2-yl)-5-methyl-2,4-dihydro-3H-p,yrazol-3-one (2) and suitably substituted araldehydes in basic medium. Further compounds 3b and 3c on cyclocondensation with phenyl hydrazine in the presence of few drops of gl acetic acid furnished the desired compounds 4a and 4b. The synthesized compounds were tested for their in vitro antimicrobial activity. Compound 3f showed maximum inhibitory activity against the tested Gram-positive bacteria Enterococcus faecalis whereas compounds 3b and 3c exhibited significant activity against Candida albicans.