Effect of non-glucose sugars and haematocrit on glucose measurements with Roche Accu-Chek Performa glucose strips.

摘要

Point-of-care blood glucose meters based on glucose dehy-drogenase (GDH) and pyrroloquinoline quinone (PQQ)-coupled reaction are subject to interference by non-glucose sugars and icodextrin metabolites, chiefly maltose.Reports of treatment of spurious hyperglycaemia, arising from the interference, with insulin leading to life-threatening/fatal hypoglycaemia caused the Food and Drug Administration and others to issue safety notices to alert health professionals of the dangers of using GDH-PQQ-based glucose monitoring systems.