Effect of memantine on lithium chloride induced head twitches in rats.

摘要

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory loss, altered behavior and signs of cortical disconnection including apraxia, aphasia and agnosia.111 Although AD was once thought to result from cholinergic deficit alone, researchers now believe that this view is simplistic.1231 Studies using human neocortical tissue have shown that multiple neurotransmitters, such as dopamine, noradrenaline, serotonin and glutamate, are decreased or dysregulated in AD. The interactive regulation of neurotransmitters complicates our understanding of the processes that work together, but may eventually permit the development of more specific drug therapies for AD.