Reductions in Urinary Collection Frequency for Assessment of Reproductive Hormones Provide Physiologically Representative Exposure and Mean Concentrations when Compared with Daily Collection

摘要

ObjectiveTo determine if reducing the frequency of urinary sample collection from daily to 5, 3, or 2 days per week during a menstrual cycle or 28-day amenorrheic monitoring period provide accurate representations of the reproductive hormone metabolites estrone-1-glucuronide (E1G) and pregnanediol glucuronide (PdG) exposure and mean concentrations.