Formulation and Evaluation of Mucoadhesive Buccal Films of Esomeprazoie Magnesium Trihydrate

摘要

The purpose of this study was to develop formulation and systematically evaluate in vitro performances of mucoadhesive patches of Esomeprazoie magnesium trihydrate using HPMC K4M, HPMC (15cps), and HPMC (5cps) for avoiding gastric degradation and prolong the release up to 8 h. The films were smooth and elegant in appearance, uniform in thickness, weight, drug content and good folding endurance. Drug and polymer incompatibility was not shown in FTIR study, in-vitro release studies were reveal that all films exhibited sustained release in range of 87.31 to 98.04% for a period of 8 h. Ex-vivo permeation studies of Esomeprazoie magnesium trihydrate were shown in the range of 84.35 to 91.33%.The best mucoadhesive performance and prolonged release was exhibited by formulation F_2. Formulation F_2 was shown 91.45% drug release after 8 h and 28.4 gm mucoadhesive force. It was followed zero order drug release pattern and non-fickian release behavior. Therefore, buccal patches containing HPMC K4M (3%) was shown satisfactorily results for alternative route of administration of Esomeprazoie magnesium trihydrate for avoiding gastric degradation and sustain release.