Rotational equilibria in boat conformations of N-acyl-r-2,c-6-di(2-heteroaryl)piperidin-4-ones using NMR spectra and semiempirical MO calculations

摘要

Four N-acyl-r-2,c-6-di(2-heteroaryl)piperidin-4-ones 3-6 have been prepared and their conformational preferences examined using H-1 and C-13 NMR spectral studies and semiempirical MO calculations. Solution state conformational studies on the compounds 3-6 by H-1 and C-13 NMR spectral methods indicated the preference for the boat conformation with coplanar orientation of N-acyl groups. The energy barrier for N-C rotation in 3 has been found to be 58.4 kJ mol(-1) using variable temperature H-1 NMR spectral studies. The semiempirical MO calculations, using AMI method, also suggested the preference of boat conformation for the N-acyl derivatives 3-6.