Synthesis of pyrazolines,isoxazolines and aminopyrimidines as biological potent agents

摘要

Chalcones,2-phenylamino-4-(4'-fluorophenylamino)-6-[4'-{3"-(phenyl/substituted phenyl /2"'-furanyl/3'"-pyridinyl)-2"-propenon-l"-yl} phenylamino]-s-triazines 6a-j have been prepared from ketone 5 based on s-triazine nucleus.These chalcones 6a-j on cyclisation with hydrazine hydrate,hydroxylamine hydrochloride and guanidine nitrate give the corresponding pyrazolines 7a-j,isoxazolines 8a-j and aminopyrimidines 9a-j,respectively.Antimicrobial activities of all synthesized compounds have been performed by using cup-plate method against bacteria and by using poisoned food technique against fungi.The constitutions of newly synthesized compounds have been established on the basis of elemental analysis,IR and ~1H NMR spectral data.