Synthesis and anticancer activity of some new series of 1, 4-dihydropyridine derivatives

摘要

A series of 1,4-dihydropyridine derivatives 1a-c have been prepared from 4-substituted aromatic aldehyde, ethyl acetoacetate and ammonium hydroxide following Hantzsch method. The compounds 1a-c have been reacted with semicarbazidc to give the compounds 2a-c. The compounds 1a-c have been reacted with thiosemicarbazide to give the compounds 3a-c. The structures of synthesized compounds are confirmed by IR, ~1H and ~(13)C NMR, mass spectrometry and elemental analyses. The newly synthesized compounds have been screened for preliminary anti-cancer activity against HepG2 (Liver), Hela (Cervical) and MCF-7 (Breast) cancer cells. The compound 2a is highly active against HepG2, MCF-7 and 3a is highly active against Hela (Cervical) and these have been selected for advanced preclinical development.