Enantiospccific total synthesis of ent-5-senecioyloxy-10,11-epoxythapsan-10-ol

摘要

Enantiospccific total synthesis of optical antipode of the sesquiterpene 5-senecioyloxy-10,11-epoxythapsan-10-ol has been described. (R)-Carvonc has been employed as the chiral starting material and a combination of intramolecular alkyation and Cricgec fragmentation are employed for intramolecular stereospecific transfer of the chirality. An intramolecular diazokctone cyclopropanation and regioselective cyclopropane ring cleavage reactions have been employed for the creation of the three requisite contiguous quaternary carbon atoms.