Thienopyrimidines as hetryl moiety in 2-azetidinones:Synthesis of 4-hetryl-2-azetidinones

摘要

A Facile and efficient method for the synthesis of 4-hetryl substituted beta-lactams 1 have been reported from substituted thienopyrimidinone 2b,which in turn was prepared from appropriately substituted 2-amino-3-carboxamido thiophene 10.The structures of newly synthesized compounds have been established through spectral and analytical analysis.It is evident from the literature that both thienopyrimidinone and 2-azetidinones are well known for their varied biological activities such as high affinity selective 5-HT_(1A)receptor ligands,potential anti-hypertensive agents,molluscicidal and larvicidal activities,anticonvulsant and anti-bacterial activity,and cholesterol inhibition activity.