Uses of quinazolin-2-[(#beta#-propionoyl)isothiocyanate]-4-one as a building block in synthesis of some heterocyclic compounds of expected biological activity

摘要

The behaviour of quinazaline-2 [(#beta#-propionoyl)isothiocyanate] 1 towards different nucleophilic reagents as phenylhydrazine, aroyl hydrazine, glycine, anthranilic acid (nitrogen nucleaphile), sulphut nucleaphile as a thioglycolic acid and oxygen nucleaphile as ortho amino phenol has been investigated and found that it proceeds via isothiocyanate heterocyclization to furnish non-condensed heterocyclic compounds containing triazoles, oxazole, thiazole and benzoxazale nuclei besides the quazoline nucleus.