THE CYTOTOXIC INTERACTION OF INORGANIC TRACE ELEMENTS WITH EDTA AND CISPLATIN IN SENSITIVE AND RESISTANT HUMAN OVARIAN CANCER CELLS

摘要

Cisplatin (CDDP)-sensitive and -resistant human ovarian cells were studied in vitro with the objective of enhancing CDDP cytotoxicity by the addition of a metal and the chelate ethylenediaminetetiaacetic acid (EDTA), to the CDDP. Chelateable elements,such as bismuth, calcium, cadmium, copper, iron, magnesium, selenium, vanadium, and zinc, when added to CDDP and in the presence of EDTA increased the cytotoxicity of the CDDP as compared to CDDP treatment alone.