Innovative Breast Cancer Biomarkers.

摘要

The enormous technological developments characterizing the last decades of cancer research made possible the interpretation of several biological phenomena peculiar of cancer cells. However, after many efforts in the search for clinical application of this know-how in terms of new biomolecular markers for risk, prognosis, and prediction of therapeutic efficacy still only few examples of their utilization in clinical practice are available. One reason for this could be the lack of translation into routine practice; other frequently cited reasons are the low quality of the validation studies performed so far [1] and the need for an optimization of the process leading the bio-marker from basic research to clinical practice [2].