Irisin, a Novel Myokine Responsible for Exercise Induced Browning of White Adipose Tissue

摘要

Exercise is known to induce weight loss which is more than expected due to energy expenditure during exercise. Till now the molecular mechanism of this disproportionate loss in weight was not known. A novel myokine, Irisin named after Greek goddess iris, discovered by Brace M. Spieg-elman et al. in 2012 [1] has been found to be the hormone responsible for exercise induced improvement in glucose homeostasis. It is a 112 AA polypeptide secreted from muscle into the bloodstream in response to exercise. There is 100 % homology in structure of Irisin between human and mice suggesting it to be a highly conserved hormone during evolution. It is found to be responsible for browning of subcutaneous adipose tissue and thus it is responsible for antiobesity and antidiabetic effect [1].