Antimicrobial resistance and prudent drug usefor Streptococcus suis

摘要

This paper reviews information on antimicrobial resistance patterns and prudent use ofantimicrobials to reduce the impact and spread of resistant Streptococcus suis strains. S. suis isan important pathogen in swine, which can cause significant economic loss. Prudent use ofantimicrobials for S. suis is essential to preserve the therapeutic efficacy of broad-spectrumantimicrobials and to minimize selection of resistant S. suis strains. Resistance of S. suis toantimicrobials commonly used in swine, including lincosamides, macrolides, sulphonamides,and tetracycline, has been documented worldwide, with resistance in up to 85% of strains.Among antimicrobials examined, resistance of S. suis has been demonstrated to be relativelylow for penicillin (0–27%), ampicillin (0.6–23%), and ceftiofur (0–23%). For penicillin, thisresult may be due in part to the unique mechanism by which resistance is acquired throughmodifications in the structure of penicillin-binding proteins. Recommendations to controlS. suis infection include focused and careful choice and appropriate use of antimicrobials,together with preventive measures intended to improve swine management.