American Association for Cancer Research--100th Annual Meeting. New therapeutic developments: part 2. 18-22 April 2009, Denver, CO, USA.

摘要

The naturally occurring compound PM-01183 (PharmaMar SA) Is an alkaloid that binds DNA, causing delayed progression of the S phase of the cell cycle and cycle arrest at G_2M. Pablo M Aviles from PharmaMar described a study in which the cytotoxicity of PM-01183 was examined in CHO-derived isogenic cell lines with normal or impaired DNA repair function. In nucleotide excision repair (NER)-deficient cells, the compound was 3- to 4-fold less potent than in normal cells, but was 100-fold more potent in homologous recombinant (HR)-deficient cells.