In vitro Interaction of H1 and H2-receptor Antagonists, Cephalosporins, ACE-inhibitors, Hydrochlorothiazide, NSAIDs and Quinolones with Amantadine

摘要

Amantadine was discovered in petroleum and name is derived from Greek name adamantinos (relating to steel or diamond), due to its diamond-like structure. The in vitro availability of H1 and H2-receptor Antagonists, Cephalosporins, ACE-inhibitors, Hydrochlorothiazide, NSAIDs and Quinolones with Amantadine was studied on a Compact Dissolution Test Apparatus-Type PTWS 310 manufactured by Pharmatest according to USP/EP. To observe the percentage availabilities of different classes of drugs in presence of amantadine were carried out at 37DC in simulated gastric juice as it was insoluble at all other pH levels found in human body. Results reflect the possible complexation of these drugs with amantadine. The in vitro availability of all drugs was found to be markedly retarded in the presence of amantadine.