New Strategies for Rapid F-18-Radiolabeling of Biomolecules for Radionuclide-Based In Vivo Imaging

摘要

The increasing availability of highly active no-carrier-added [F-18]-fluoride makes its use in radiolabeling biomolecules attractive. By incorporating "fluorophilic" elements (Si, B, and Al) into biomolecules, recent advances offer mild and rapid F-18-labeling approaches without HPLC purification at the radiosynthetic stage while maintaining sufficient specific activity. In this Topical Review, we will discuss the most recent strides in the field.