Synthesis of Nitrogen Heterocycles by Rhodium-Catalyzed Hydroformylation of Polymer-Attached Amino Alkenes with Syngas

摘要

Rhodium(I) phosphite catalyzed hydroaminomethylation of resin-tethered amino alkenes with H_2/CO gives moderate to good yields of five-,eight-,ten-,and thirteen-membered heterocycles.Competing hydrogenation,dimerization,or polymerization reactions were not observed using this methodology.