Synthesis of Polycyclic Nitrogen Heterocycles via Cascade Pd-Catalyzed Alkene Carboamination/Diels-Alder Reactions

摘要

Cascade Pd-catalyzed alkene carboamination/Diels-alder reactions between bromodienes and amines bearing two pendant alkenes are described. These transformations generate 4 bonds, three rings, and 3–5 stereocenters to afford polycyclic nitrogen heterocycles with high diastereoselectivity.