Parents' attitudes toward methylphenidate using n-of-1 trial: a pilot study

摘要

To compare parents' attitudes toward methylphenidate treatment in children with attention deficit hyperactivity disorder employing two approaches: (1) a 2-week double-blind placebo-drug trial (n-of-1 trial), (2) a traditional prescription approach. The study group (N-50) and a comparison group (N-45) were recruited. The Abbreviated Acceptability Rating Profile was administered prior to and following the pediatricians' consultation, and in 2, 4, and 8 weeks after prescription. Complete data set was available for 21 children in each group. While initial attitudes were similar, a significantly more favorable attitude following the performance of an n-of-1 trial and throughout the follow-up in the study group only was noted. Adherence was significantly correlated with attitude score in the study group only. An individual n-of-1 trial with methylphenidate appears to positively affect parents' attitudes toward drug treatment and may also help adherence with this treatment.