Self-measured blood pressure monitoring in the management of hypertension: A systematic review and meta-analysis

摘要

Background: Clinical guidelines recommend that adults with hypertension self-monitor their blood pressure (BP). Purpose: To summarize evidence about the effectiveness of selfmeasured blood pressure (SMBP) monitoring in adults with hypertension. Data Sources: MEDLINE (inception to 8 February 2013) and Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews (fourth quarter 2012). Study Selection: 52 prospective comparative studies of SMBP monitoring with or without additional support versus usual care or an alternative SMBP monitoring intervention in persons with hypertension. Data Extraction: Data on population, interventions, BP, other outcomes, and study method were extracted. Random-effects model meta-analyses were done. Data Synthesis: For SMBP monitoring alone versus usual care (26 comparisons), moderate-strength evidence supports a lower BP with SMBP monitoring at 6 months (summary net difference, -3.9 mm Hg and-2.4 mm Hg for systolic BP and diastolic BP) but not at 12 months. For SMBP monitoring plus additional support versus usual care (25 comparisons), high-strength evidence supports a lower BP with use of SMBP monitoring, ranging from-3.4 to-8.9 mm Hg for systolic BP and from-1.9 to-4.4 mm Hg for diastolic BP, at 12 months in good-quality studies. For SMBP monitoring plus additional support versus SMBP monitoring alone or with less intense additional support (13 comparisons), low-strength evidence fails to support a difference. Across all comparisons, evidence for clinical outcomes is insufficient. For other surrogate or intermediate outcomes, low-strength evidence fails to show differences. Limitation: Clinical heterogeneity in protocols for SMBP monitoring, additional support, BP targets, and management; follow-up of 1 year or less in most studies, with sparse clinical outcome data. Conclusion: Self-measured BP monitoring with or without additional support lowers BP compared with usual care, but the BP effect beyond 12 months and long-term benefits remain uncertain. Additional support enhances the BP-lowering effect. Primary Funding Source: Agency for Healthcare Research and Quality.