N-Heterocyclic-Carbene-Catalyzed Regioselective Oxidative Ring-Opening of Epoxides with Aromatic Aldehydes: A Facile Entry to alpha-Acyloxyketones

摘要

A high-yielding synthesis of -acyloxyketones using a N-heterocyclic-carbene (NHC)-catalyzed, oxidative ring-opening of epoxides with aromatic aldehydes is described. This regioselective, oxidative process utilizes a N-bromosuccinimide (NBS)/DMSO combination as the oxidant system and Et3N as the base under mild reaction conditions.