ASSESSMENT OF LEPTIN HORMONE AND VITAMIN C IN PATIENTS WITH TYPE 2 DIABETES MELLITUS IN NAJAFGOVERNORATE, IRAQ

摘要

The search for new parameters for monitoring and even prediction of diabetes mellitus (DM) are still an important issue in many research fields. Some studies focused on role of insulin status, while others concentrated on lipid disturbances or even oxidative stress disorders in the diabetes. The study was conducted by taking 66 type 2 diabetic patients (NIDDM) (32 males and 34 females) attending the diabetes mellitus center in Al-Sadder Teaching City in Al- Najaf province and a group of 21 apparentlyhealthy subjects (9 Males and 12 Females) were included as a control group. The study was carried out from August 2012 to February 2013. The age of patients and control groups were in the range of 35-65 years old. The concentration of fasting blood glucose (FBG), cholesterol, triglyceride (TG), HDL, leptin and vitamin C were measured, also VLDL, LDL and BMI were estimated in patients and the control groups. The results show significant decrease (p<0.05) leptin, vitamin C and HDL levels in patients compared with control groups , also the results show significant increase (p<0.05) in FBG, cholesterol ,TG,LDL and VLDL levels in patients compared with control groups. The results show significant negative correlation (p<0.05) among leptin with FBG and HDLin patients. The results have shown significant positive correlation (p<0.05) among leptin with cholesterol, TG, LDL and VLDL in patients. Also the results have shown no significant correlation (p<0.05) between leptin and vitamin C in patients. The present study concluded that leptin and vitamin C levels were markers for detection and diagnosis of diabetic patients type 2.