Thermal Stability and Properties of a New CRF1 Antidepressant Compound (C_(22)H_(28)N4O4) from Low-Temperature Molar Heat Capacity

摘要

Low-temperature heat capacities of a new CRF, antidepressant compound C_(22)H_(28)N4O4 were measured by a temperature modulated differential scanning calorimetry in the temperature range from T = 188 to 562 K. An obvious endothermic process took place in the temperature range of 353-372 K. The peak in the heat capacity curve was corresponding to the fusion. The experimental molar heat capacities in the temperature range of 193-353 and 372-562 K were fitted to the polynomial. The thermodynamic functions, (H_T - H_(298.15) K) and (S_T - S_(298.15) K), of the compound had been calculated by the numerical integral of the heat-capacity polynomial.