One-Pot Synthesis of Dimannopyranosylbenzene (or Pyridine) and Dimannosyl-1,8-diaminooctane

摘要

The one-pot synthesis of divalent of mannose disaccharides, of potential use as anti-infective agents against enterobacteria infections, described. We report one-pot synthesis of dimannopyranosylbenzenes (6, 7, 8), dimannosyl-2,6-diamino-pyridine (9) and dimannosyl 1,8-diaminooctane (10). But the reaction of 8-(2-amino-pyridin-3-yl)-8-azabicyclo[3.2.1]octane-3-one (11) as a monoamine and D-(+) mannose did not occur. The results implied that compound 12 is not produced due to steric hindrance of tropane ring.