Increased Production of Interleukin-17 Over Interleukin-10 by Treg Cells Implicates Inducible Costimulator Molecule in Experimental Spondyloarthritis

摘要

Objective. HLA-B27/human beta(2)-microglobulin (h beta(2)m)-transgenic (B27-transgenic) rats develop an inflammatory disorder resembling spondyloarthritis, with accumulation of proinflammatory Th17 cells. Because Treg cells and Th17 cells have opposing effects in inflammatory disorders, we sought to determine whether biased expansion of Th17 cells could result from altered Treg cell frequency and/or function in B27-transgenic rats.