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首页> 外文期刊>ASAIO journal >Verification of a computational cardiovascular system model comparing the hemodynamics of a continuous flow to a synchronous valveless pulsatile flow left ventricular assist device
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Verification of a computational cardiovascular system model comparing the hemodynamics of a continuous flow to a synchronous valveless pulsatile flow left ventricular assist device

机译:验证了计算心血管系统模型的效果,该模型比较了连续流与同步无阀脉动流左心室辅助装置的血流动力学

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摘要

The purpose of this investigation is to use a computational model to compare a synchronized valveless pulsatile left ventricular assist device with continuous flow left ventricular assist devices at the same level of device flow, and to verify the model with in vivo porcine data. A dynamic system model of the human cardiovascular system was developed to simulate the support of a healthy or failing native heart from a continuous flow left ventricular assist device or a synchronous pulsatile valveless dual-piston positive displacement pump. These results were compared with measurements made during in vivo porcine experiments. Results from the simulation model and from the in vivo counterpart show that the pulsatile pump provides higher cardiac output, left ventricular unloading, cardiac pulsatility, and aortic valve flow as compared with the continuous flow model at the same level of support. The dynamic system model developed for this investigation can effectively simulate human cardiovascular support by a synchronous pulsatile or continuous flow ventricular assist device.
机译:本研究的目的是使用计算模型将同步无阀脉动左心室辅助设备与连续流量左心室辅助设备以相同的设备流量进行比较,并使用体内猪数据验证该模型。开发了人类心血管系统的动态系统模型,以模拟来自连续流动的左心室辅助设备或同步脉动无阀双活塞正排量泵对健康或衰竭心脏的支持。将这些结果与体内猪实验期间的测量结果进行了比较。仿真模型和体内对应物的结果表明,与在相同支持水平下的连续血流模型相比,脉动泵提供更高的心输出量,左心室卸载,心脏搏动性和主动脉瓣血流。为此研究开发的动态系统模型可以通过同步脉动或连续流心室辅助设备有效模拟人类的心血管支持。

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