Highlight report: Towards the replacement of in vivo repeated dose systemic toxicity testing

摘要

Recently, the European Union, together with the European cosmetics industry represented by Colipa, initiated the "SEURAT-1" program to develop in vitro and in silico test systems with the goal to eventually replace in vivo repeated dose systemic toxicity testing. The results and concepts will be published in a series of six annual books, the first of which was recently released (Schwarz and Gocht 2011).