Overweight decreases the chance of achieving good response and low disease activity in early rheumatoid arthritis

摘要

Obesity and overweight are increasingly prevalent risk factors for many chronic diseases and also decrease the quality of life.1 Approximately 35% of the world population is estimated to be overweight/ obese.Due to the immunomodulating and proin-flammatory properties of adipose tissue, it is of particular interest to study whether overweight may influence disease activity in rheumatoid arthritis (RA). Indeed, several studies have evaluated the effect of high Body Mass Index (BMI) on different aspects of this heterogeneous disease (reviewed in). Recent reports have indicated that RA patients with high BMI have a worse long-term outcome in terms of disease activity, function and comorbidities (BARFOT,); and respond worse to tumour necrosis factor (TNF) inhibitors,even the weight-adjusted infliximab treatment. In an early RA trial (BeSt), BMI only associated with response to combination treatment, not methotrexate monotherapy.